Acne vulgaris is a disorder characterized by chronic inflammation of blocked pilosebaceous follicles. It predominantly affects teenagers. Some aetiologiacal factors are increase in sebum excretion, which is probably androgen mediated, Increased and abnormal keratinisation at the exit of the pilosebaceous follicle causes obstruction to the flow of serum and the sebum patients with acne contains an excess of free fatty acids ,which may be responsible for triggering the inflammatory process. The main clinical features are lesions are limited to the face, shoulders, upper chest and back, seborrhea is often present, open comedowns are due to plugging of the pilosebaceous orifice by keratin and sebum, closed comedowns are due to accretions of sebum and keratin deeper in the pilosebaceous ducts. Local managements are regular washing of soap and water, antibacterial skin cleansers containing chlorhexidine, preparations containing benzyl alcohol and retinoic acid. But the systematic measures are long term antibiotic therapy with oxytetracycline, minocycline, or erythromycin for duration of 3 months to 2 years, Isotretinonin given in a four month course can reduce sebum excretion and hormonal treatment in the form of a combined anti-androgen pill, can be given in courses as an oral contraceptive. Physical measures are incision and drainage of cysts.
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